Interesting thoughts on the limits of human comprehension of the universe

I thought the first comment to this post on DarwinCatholic was interesting:

[Carl Sagan] laid out a hypothetical world that exists only in two dimensions. The inhabitants of this world were flat pieces of paper moving about on a plane (a tabletop). One day an apple visits this world. Sagan dipped the bumpy bottom of the apple on an inkpad and set it down amid the flatworlders. To them, he said, the apple appears as four, distinct objects where the ink marks the tabletop. Their dimensionality prevents them from seeing the rest of the apple as it truly exists in three dimensions...One could argue that it also shows the weak spot of science if it bows to methodological materialism and only adheres to observations made with the five senses.